Natural Products | Uses for Supercritical Fluids

The term natural products has become the "catch-all" for any compound that has been produced by a living being, e.g. plant, animal, algae. The extracted compounds are used in, or are themselves, foods, medicinals, pigments, fragrances. The process for many years was to extract from the matrix material by solvents: aqueous and petroleum based. The first large scale use of supercritical fluids in extracting natural products was the decaffeination of coffee in 1979 and since then thousands of compounds have been extracted commercially.

Why the interest in using supercritical fluids (i.e. CO2)?


No Solvent residue. No health hazard.
Maintains a "natural" state.

Supercritical CO2 extracts the various natural compounds more efficiently than petroleum based solvents, but upon returning to an ambient state, the CO2 becomes a gas, leaving no residue.


Mild Extraction Conditions – 31°C temperature

With temperatures less than body temperature (37°C), little thermal degradation of sensitive compounds occurs. (See phase diagram.)


Fractionation - easy using only CO2: CO2 is a “tunable solvent”

Load the feedstock into an extraction vessel only once and then by only changing pressure of the supercritical CO2, you can make it have the solubility characteristics of a myriad of petroleum based solvents. You don’t need to add or change solvents.

Which Supercritical System is Right for My Application?

You've got your method down and it's time to start production.

When you're ready to go, and need a mid-sized system to make it happen.

You have small amounts to process, or you need to perfect your method.

Applied Separations, Inc.     930 Hamilton St., Allentown, PA 18101     610-770-0900